Voriconazole Pharmacokinetics and Therapeutic Drug Monitoring : A Multi - Center Study
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چکیده
Voriconazole Pharmacokinetics and Therapeutic Drug Monitoring: A Multi-Center Study 1 2 Michael J Dolton, John E Ray, Sharon C-A Chen, Kingsley Ng, Lisa G Pont, Andrew J 3 McLachlan 4 5 1 Faculty of Pharmacy, University of Sydney, Camperdown, Australia 6 2 Clinical Pharmacology & Toxicology, SydPath, St Vincent’s Hospital, Darlinghurst, 7 Australia 8 3 Centre for Infectious Diseases & Microbiology and the University of Sydney, Westmead 9 Hospital, Westmead, Australia 10 4 Department of Pharmacy, Westmead Hospital, Westmead, Australia 11 5 Centre For Education and Research on Ageing, Concord Repatriation General Hospital, 12 Concord, Australia 13 14 *Corresponding Author: 15 Professor Andrew McLachlan 16 Faculty of Pharmacy 17 University of Sydney NSW 2006 18 Australia 19 Tel: +61 2 9767 7373 20 Fax: +61 2 9351 6950 21 Email: [email protected] 22 23 Copyright © 2012, American Society for Microbiology. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.00626-12 AAC Accepts, published online ahead of print on 2 July 2012
منابع مشابه
Pharmacokinetics and Therapeutic Drug Monitoring : A Multi - Center Study
Voriconazole Pharmacokinetics and Therapeutic Drug Monitoring: A Multi-Center Study 1 2 Michael J Dolton, John E Ray, Sharon C-A Chen, Kingsley Ng, Lisa G Pont, Andrew J 3 McLachlan 4 5 1 Faculty of Pharmacy, University of Sydney, Camperdown, Australia 6 2 Clinical Pharmacology & Toxicology, SydPath, St Vincent’s Hospital, Darlinghurst, 7 Australia 8 3 Centre for Infectious Diseases & Microbiol...
متن کاملVoriconazole Pharmacokinetics and Therapeutic Drug Monitoring : A Multi
Voriconazole Pharmacokinetics and Therapeutic Drug Monitoring: A Multi-Center Study 1 2 Michael J Dolton, John E Ray, Sharon C-A Chen, Kingsley Ng, Lisa G Pont, Andrew J 3 McLachlan 4 5 1 Faculty of Pharmacy, University of Sydney, Camperdown, Australia 6 2 Clinical Pharmacology & Toxicology, SydPath, St Vincent’s Hospital, Darlinghurst, 7 Australia 8 3 Centre for Infectious Diseases & Microbiol...
متن کاملمروری بر فارماکوکنتیک و فارماکودینامیک وریکونازول
Voriconazole is an antifungal triazole, approved for management of invasive fungal diseases in patients. It is absorbed during two hours and its serum levels will be above 90%, based on the underlying factors, when the drug is administered orally. Voriconazole shows a propotional increase in an area under the plasma concentration-time curve (AUC), with increasing dose. Plasma protein binding of...
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Voriconazole is an antifungal triazole that is the first line agent for treatment of invasive aspergillosis. It is metabolized by CYP2C19, CYP2C9, and CYP3A4 and demonstrates wide interpatient variability in serum concentrations. Polymorphisms in CYP2C19 contribute to variability in voriconazole pharmacokinetics. Here, evidence is examined for the use of voriconazole therapeutic drug monitoring...
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